MND funding opportunities

Applications for our 2025 Advancing Treatment Awards are now open.

Our 2025 Advancing Treatments Award will support the early-stage development of new treatments to slow, stop or reverse MND disease progression. We will also consider the development of treatments to better manage the symptoms of MND, where they could transform the lives of people living with the condition. We encourage applications for projects with the potential to be effective across a broad range of people living with MND. 

The Award aims to help researchers build data packages that will attract onward investment and strategic partnerships to accelerate promising treatments through further testing and towards commercialisation.

Scope

We are accepting applications for projects across two of the strategic priorities in our research strategy:

1. Validate therapeutic targets 

          We will support studies to robustly validate novel targets for MND treatments

2. Accelerate new treatments

          We will support the pre-clinical development of novel or repositioned pharmacological interventions for MND

For projects focusing on validating therapeutic targets, we expect applicants to be able to demonstrate the target's relevance (i.e. biological rationale), differentiation, and safety. Applicants must clearly outline how they will demonstrate that target modulation results in pathway modification and rescue of disease phenotype. Successful projects will seek to define target engagement and downstream pharmacodynamic biomarkers.

For projects focused on accelerating new treatments, we will support the development of new pharmacological interventions and studies to demonstrate their efficacy in pre-clinical models. Projects must assess target engagement and build a robust body of evidence using multiple relevant models or approaches. We will also support safety and pharmacokinetic studies, enabling human dose prediction. Successful studies will consider the development of biomarker and patient stratification approaches.

For further guidance, please read our guidance on implementing the Guiding Principles for Drug Discovery and Development in ALS.

Out-of-scope research includes early discovery research aimed at identifying novel targets, clinical trials, and health and social care research.

Eligibility 

Lead applicants must be based in a UK academic institution, although collaborators may be based anywhere worldwide.

We encourage early career researchers (ECRs - senior postdocs working towards independence) to apply as lead and co-applicants. Applications must be accompanied by a letter of support from both the ECR’s host institution and principal investigator. 

Sub-contracting to contract research organisations is permitted and industry partnerships are encouraged, but pharmaceutical and biotech companies are not eligible for grant funding.

Projects that leverage additional funding sources or in-kind support will be looked upon favourably.

Funding

Eligible expenses include costs for research staff, consumables, and expenses related to conferences and publications. Requests for funding to cover other items must be pre-approved by the Foundation before application.

The Foundation does not cover indirect research costs.

Awards are for a maximum of £500k for up to 5 years, unless otherwise pre-agreed with the Foundation. Projects exceeding £300k or 3 years should be milestone-gated with clear go/no-go decisions built in.

We are happy to explore co-funding projects with other funders. Applicants must be able to demonstrate that funding for the total cost of the project has been secured.

A maximum of £1.5m million is available for this grant round, depending on suitable quality applications.

Application process and timeline

All applications are to be made using our online grant management system, Flexi-Grant.

Key dates are outlined below:

18th March 2025 - Applications are open for Expression of Interest (EoI)

2nd of May, midday - Deadline for Expression of Interest (EoI)

June - Successful EoIs are invited to Full Application stage

July - Deadline for Full Applications

November - Anticipated Award decision

Assessment criteria

Applications will be assessed by our independent Research Review Committee. Please note this committee is made up of scientific experts and people affected by MND, who score the applications with equal weighting.

Applications will be assessed according to the following criteria:

• Good communication of research with non-scientific audiences audiences (lay summaries that are not understandable will be sent back before a full review is completed. Please see Muscular Dystrophy UK's guidance on how to write a lay summary)
• Strategic fit and potential impact for people with MND
• Scientific robustness of the proposal including strength of existing evidence, methodology proposed and level of scientific innovation
• Alignment to the Guiding Principles for Drug Discovery and Development in ALS
• If animal use is proposed and justified, the appropriateness of number of animals and chosen models
• Suitability of the applicant(s) to carry out the research
• Potential of the project to rapidly translate towards the clinic
• Appropriateness of patient and public involvement, such as whether the ask of people affected by MND in the proposal is reasonable
• Appropriateness of mitigation of risks associated with the project
• Cost effectiveness, justification of funds requested and feasibility of the approach within the proposed budget and timescale

Full terms and conditions for the Advancing Treatments Award can be found here.

Making an application

My Name’5 Doddie Foundation is committed to supporting you throughout your project funding journey, beginning with the chance for 1:1 support even before you submit your Expression of Interest (EoI). This step can be invaluable in strengthening your submission. Should you wish to book a 1:1 or have any queries about the Advancing Treatments Award or the application process, please do not hesitate to contact us at research@myname5doddie.co.uk.

Previous success rate

In 2024, for our Advancing Treatments Award we received 8 expressions of interest, 7 were invited to full application stage and 5 projects were awarded funding. In 2023, for our Advancing Treatments Award (previously “Project Award”) we received 9 expressions of interest, 5 were invited to full application stage and 3 projects were awarded funding.

Applications for our 2025 Discovery Network Awards are now open.

People living with MND urgently need effective treatments. To catalyse the search for these treatments, the Discovery Network was first launched in 2024, with details of this first round now available here.

The Discovery Network is a new funding opportunity for interdisciplinary, multi-institutional teams to apply for £1 million over 3 years. Teams will take on bold ideas and innovative approaches to better understand the biology of MND, with a focused goal of identifying new therapeutic targets. The Network will be underpinned by a culture of collaboration and open science. My Name’5 Doddie Foundation will facilitate activities of the network and create opportunities for rapid translation of promising findings.

Aligned to the UK MND Research Institute, the Discovery Network will be joined up within the UK MND research ecosystem, enabling access to expertise and creating a national translational pipeline.

Scope

Each team will focus on a specific area of MND biology and build on existing expertise, knowledge and tools already developed and accessible within the team. Examples of areas of MND biology may include: autophagy, ageing, the immune system, lysosomal function, mitochondrial function, protein homeostasis, RNA metabolism and vesicle transport, although this is not an exhaustive list. The Foundation welcomes proposals in new or emerging areas of MND research if supported by robust scientific evidence. Successful applications will provide preliminary data linking the focus of their project to MND development or progression and outlining the potential to reveal new therapeutic targets. 

Due to the previously successful teams’ focus on TDP-43 and ribonucleoprotein biology, other areas may be prioritised by the Advisory Board to diversify the projects within the Discovery Network. 

Teams will employ a range of innovative techniques, methodologies and expertise to gain new disease insights. This may include new approaches in omics technologies, functional genomics, imaging, complex cell models, artificial intelligence and data-driven research. We encourage the use of a range of models including human iPSCs, animal models (where absolutely needed) and human tissue samples. Use of high quality patient datasets are also encouraged.

Eligibility and funding

• Teams must be interdisciplinary and multi-institutional (minimum 2 separate research institutions)
• The lead applicant must be based within a UK academic institution, but collaborators can be based elsewhere in the world
• We encourage early career researchers (ECRs), such as senior postdoctoral researchers working towards independence, to apply as lead and/or co-applicants; they must provide a letter of support from their research institution and head of laboratory for their application. Depending on the experience of the ECR applicant, the Advisory Board may request that the head of laboratory/mentor and ECR be co-lead investigators on the project to ensure adequate support and mentorship for the ECR lead.
• Commercial companies (such as pharmaceutical and biotech companies) can be named as co-applicants but will not receive grant funding and must adhere to our policies including our open science policy

Each team will receive up to £1 million. The total fund available in 2025 is £2 million.

Application process and timeline

All applications are to be made using our online grant management system, Flexi-Grant. Key dates are tentatively outlined below:

• RFA Released - 24th March 2025
• Expressions of Interest due - Midday 21st May 2025
• Full application invitations - End of June 2025
• Full applications due - Midday 9th September 2025
• Reviewer comments shared with applicants - w/c 10th October 2025
• Response letter due - 24th October 2025
• Decisions communicated - December 2025
• Research begins - March/April January 2026

Assessment criteria

Applications will be assessed by our independent Advisory Board according to the following criteria:

• Scientific merit of the study including ambition of the aims and objectives, proposed methodology, resources and equipment and level of scientific innovation
• Technical feasibility of the project plan and likelihood of study aims and objectives being reached
• Potential impact of the project, based on its ability to reveal promising new targets for future MND treatments
• Suitability of the team to carry out the research, including access to relevant expertise and capabilities
• Ability of the team to bring valuable tools, capabilities or resources to the Discovery Network 
• Likelihood of a successful collaboration across the team
• Commitment of the team to open science and collaboration
• A cost-effective and realistic budget

Matchmaking

If you are interested in providing your expertise and becoming part of a team, the Foundation executive will provide a matchmaking function to interested applicants. Get in touch to discuss further on research@myname5doddie.co.uk. 

Making an application

Before you apply, please read our Request for Applications, which provides more detailed information on the Discovery Network and application process. You can find the Discovery Network's Open Science policy here.

To register for an account and start your application for the Discovery Network, visit Flexi-Grant.

If you are interested in submitting an application, we encourage you to get in touch with us to discuss your proposal first at research@myname5doddie.co.uk. 

Previous success rate

In 2024, for our Discovery Network Awards, we received 21 expressions of interest: eight were invited to the full application stage and four projects were awarded funding. 

Our acknowledgements

The Discovery Network is underpinned by a model born out of the Milken Institute and applied in Parkinson’s and bipolar disorder. We would like to extend our thanks to the team at BD² for sharing their knowledge and expertise with us, to help us establish this programme.

Find out more

Our Director of Research, Jessica Lee, introduced the Discovery Network 2024 round and application details in the video below.

As part of our commitment to investing in innovative new approaches, we are launching our Catalyst Awards again for 2024. We're looking for bold, innovative, early-stage ideas that need catalytic funding to get off the ground. We want to fund the kind of exciting research that could open up new treatment avenues, offer new ways to diagnose MND earlier or have the potential to transform translational research in MND.

Scope

We will support projects that aim to gather proof-of-principle data for innovative new approaches and enable researchers to bring early-stage promising ideas to life. Successful projects will generate preliminary data that will unlock further investment opportunities.

All Catalyst Awards must align to one of the strategic priorities below. Examples of the type of research that would fall into these categories are outlined below but please note, this list is not exhaustive.

• Validate therapeutic targets - Robust studies to explore and better understand MND biology, with a view to identifying and/or characterising new targets for future MND treatments.
• Improve translation - Innovative ideas to improve the translation of new MND treatments from lab to clinic, including but not limited to: investigation into novel patient stratification approaches; identification and characterisation of novel biomarkers for the diagnosis or monitoring of MND; research to enable earlier detection of MND such as identification of high-risk groups or screening tools.

Applicants should make it clear how, within one year, the project will create a new dataset on an early-stage idea or hypothesis that could open up a new research avenue, and have a clear plan for follow-on funding if their project is successful.

Eligibility and funding

• Lead applicants must be based in a UK academic institution. Collaborators can be based anywhere in the world. Industry can partner on Awards but cannot recieve grant funding.
• Awards are a maximum of £100k for up to 1 year.
• Eligible costs include research staff costs and consumables. Other costs may be considered if the applicant has discussed it with the Foundation prior to the application being made. The Foundation does not cover the indirect costs of research.

Application process and key dates

Applications are to be made using our online grant management system, Flexi-Grant. Key dates are outlined below:

• 5th August 2024 - Applications open
• Midday 22nd November 2024  - Deadline for Full Applications
• February 2025 - Anticipated Award decision

Applicants are encouraged to get in touch with the Research Team (research@myname5doddie.co.uk) before submitting an application to ensure that proposals are in scope.

Assessment criteria

Applications will be assessed by our independent Research Review Committee according to the following criteria:

• Alignment to the Foundation's research strategy and potential of the project to lead to follow-on research that will positively impact people living with MND
• Scientific robustness and innovation
• Ability of the project to create a solid preliminary data package within a one-year timeframe
• Suitability of the applicant(s) to carry out the research
• If animal use is proposed and justified, the appropriateness of the number of animals and chosen models
• Potential to secure follow-on funding if the project is successful, and for the follow-on research to rapidly translate towards the clinic
• Cost-effectiveness, justification of funds requested and feasibility of the approach within the proposed budget and timescale

All information provided in the application form will be treated with confidentiality, see our Application Terms and Conditions for further information.

Previous success rate

In 2023 for our Catalyst Award, we recieved 9 applications and 3 projects were awarded funding.

As part of commitment to expediting the development of effective treatments for MND, we are launching a new Award in 2024 to enhance UK MND clinical research capabilities and ensure more people living with MND can access a clinical trial.

Scope

Our 2024 Clinical Research Infrastructure Awards will support clinical trial staff specialising in the delivery of MND trials. They will enable centres to either begin recruiting to MND trials for the first time, or provide additional capacity at sites that already recruit to MND trials that have the potential to expand their portfolio and increase recruitment numbers.

They do not aim to provide long-term funding for clinical research infrastructure, but to provide bridge funding that will help trial centres demonstrate their ability to set-up or expand their trial portfolio, so they can seek longer-term support to sustain activity.

In 2024, we will allocate £500,000 to these awards and are expecting to provide awards of 1-3 years. We do not expect to fund whole salaries of individuals, but contribute to salaries of existing staff who will then be able to allocate time to MND trials.

Depending on interest and success of the scheme, we intend to deliver a second round of funding in 2025, incorporating any feedback from the community.

Eligibility and funding

Lead applicants must be based in an NHS centre that either wishes to start recruiting to MND trials, or to expand its existing portfolio of MND trials.

Eligible expenses include consultant or clinical fellow programmed activity times, clinical research nurse time and administrative staff time. Requests for funding to cover other items must be pre-approved by the Foundation before application. It is important to note that the Foundation does not cover indirect research costs.

Awards are for a maximum of £125k for up to 3 years, unless otherwise pre-agreed with the Foundation.

Please note, we will not support clinical research nurse time in MND Association Care Centres and Networks as these costs are eligible for support by the MND Association through its recently announced £5 million funding. Other staff costs will be supported in these centres e.g. consultant or clinical fellow programmed activities or administrative support.

Application process and timeline

All applications are to be made using our online grant management system, Flexi-Grant. Key dates are outlined below:

• 5th August 2024 - Applications open
• Midday 22nd November 2024  - Deadline for Full Applications
• February - Anticipated Award decision

Applications will request:

• A short summary of what you’re applying for
• Information on your current MND trial activity including details of which trials are active, how many patients are recruited and current staff that specialise in MND trials
• Information on how the funding will expand your MND trial activity including which trials you plan to recruit to, how many patients you expect to be able to recruit and which staff will support the increased activity
• A summary of why your centre is poised for success in setting up or expanding its MND trial portfolio
• Any potential barriers to the recruitment of MND trials in your centre and how you plan to overcome them
• Details on how the centre will engage strategically with the other national MND trial centres and networks to coordinate activities and share knowledge
• Do you have any source of existing funds for clinical infrastructure e.g. MND-SMART, TRICALS, EXPERTS-ALS?
• Are you eligible for any other clinical research infrastructure funding e.g. MND Association Care Centre and Network funding?
• Sustainability plans; how do you aim to leverage longer-term sustainable funding following this Award?

Assessment criteria

Applications will be assessed by an independent panel. Please note this committee is made up of clinical trial experts and people affected by MND, who score the applications with equal weighting. Applications will be assessed according to the following criteria:

• Ability of the funding to support new or enhanced recruitment of patients into MND clinical trials (preference will be given to centres that plan to recruit to a number of different trials incorporating different modalities)
• Ability and plans of the centre to integrate and network with the national MND clinical landscape
• Cost effectiveness and justification of funds requested
• Potential for the centre to develop sustainable funding
• Suitability of applicants to deliver the research

All information provided in the application form will be treated with confidentiality, see our Application Terms and Conditions for further information.

Contact us

If you would like a 1:1 discussion with our team to discuss your application before submission, please get in touch with us at research@myname5doddie.co.uk.

My Name’5 Doddie Foundation, MND Association, MND Scotland and LifeArc are launching the call for funding for the next phase of the UK MND Research Institute (previously Joint Collaborative MND Partnership). 

Scope of the award

• This award will fund the core staff required to run the UK MND Research Institute and coordinate the research community.
• It will also support core research infrastructure costs i.e. facilities that provide resources and services for the research community to conduct research and foster innovation - this may include but is not limited to disease registries, biosampling efforts and patient reporting applications.
• The award will not support research activities such as basic science, translational research projects or clinical trials. The applicants are expected to apply for external research grant funding from funding bodies for individual research projects, studentships and fellowships and leveraging external grant funding will be a key measure of success of the UK MND Research Institute. 

Eligibility

• The host institution will need to be a UK research institution/ Higher Education Institution.
• The Co-Directors and other co-applicants need to be based at UK research institutions. 
• The Co-Directors should have employment contracts at their research institutions for the full duration of the award i.e. to December 2030.

Funding available 

• The applicants can apply for up to £5 million in total for a five-year period starting from 1 January 2026. As all funders are charities, only direct costs will be funded.

Timeline

• The deadline for submission is noon on Wednesday 30 April 2025. 
• A Review Committee will meet in summer 2025 to assess and interview the proposed leadership team of the UK MND Research Institute. 

Please note this application will need to be submitted through My Name’5 Doddie Foundation’s online grants system, Flexigrant. Details on how to access the system will be provided to applicants in advance of the deadline. 

To request a copy of the guidance and application form or submit any queries please contact research@myname5doddie.uk.